通过测定在免疫应答过程中脾细胞ACTH受体的变化 ,以探讨神经内分泌系统与免疫系统的相互关系。用HRBC免疫小鼠 ,采用放射配体法测定ACTH受体 ,用饱和曲线与Scatchard作图进行分析 ,结果显示小鼠脾细胞上存在ACTH受体 ,在免疫应答过程中第 7天达高峰 (P <0 0 5 ) ,并与血浆ACTH含量密切相关 (r =0 77)。提示ACTH肽类激素可能通过免疫细胞上的ACTH受体对免疫系统进行调节 The changes of ACTH receptors in spleen cells during the immune response were measured to explore the relationship between neuroendocrine system and immune system. Immunization of mice with HRBC and ACTH receptors by radioligand assay and saturation curve analysis with Scatchard plot showed that ACTH receptors were present on splenocytes of mice and peaked on day 7 of the immune response (P <0 0 5), and was closely related to plasma ACTH content (r = 0 77). Suggesting that ACTH peptide hormones may regulate the immune system through ACTH receptors on immune cells