多囊卵巢综合征(PCOS)是无排卵性不孕症的最常见原因,其发病因及发病机制尚不清楚。因具有明显的家族聚集性,认为发病与遗传因素有关,是某些致病基因与环境因素交互作用造成的。这些致病基因参与(?)体类激素的生物合成和代谢、促性腺激素的功能和调节,肥胖和能量调节及胰岛素作用中的某些环节的调节。这些调节环节的基因变异引起一系列的异常表现导致PCOS的发生。提示PCOS是基因突变与环境因素共同作用的结果 Polycystic ovary syndrome (PCOS) is the most common cause of anovulatory infertility, its etiology and pathogenesis is unclear. Due to its obvious familial aggregation, it is thought that the pathogenesis is related to genetic factors and is caused by the interaction between some pathogenic genes and environmental factors. These pathogenic genes are involved in the biosynthesis and metabolism of (?) Somatic hormones, the function and regulation of gonadotrophins, the regulation of certain links in obesity and energy regulation and insulin action. Gene mutations in these regulatory links lead to a series of abnormalities leading to the development of PCOS. Tip PCOS gene mutation is the result of the interaction with environmental factors