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目的 :探讨人工晶体植入术后房水中白介素 - 2 (IL - 2 )和肿瘤坏死因子 -α(TNF -α)水平及其与一氧化氮 (NO)的关系。方法 :将新西兰白兔随机分成 3组 :( 1)正常对照组 ;( 2 )晶体囊外摘除术组 (ECCE) ;( 3 )晶体囊外摘除术 +人工晶体囊袋内植入术组 (ECCE +IOL)。于术后 0、1、3、7、14、3 0d观察各组动物眼内炎症反应的同时 ,测定房水中IL - 2和TNF -α水平及NO2 -/NO3-含量。结果 :( 1)术后 1- 14dECCE +IOL组房水中IL - 2、TNF-α和NO2 -/NO3-含量均明显高于ECCE组和对照组 ,该含量于术后 3 - 7d达到高峰 ,2周后逐渐减少 ;( 2 )各组房水IL - 2、TNF -α和NO2 -/NO3-含量变化的规律一致 ,房水IL - 2和TNF -α水平与NO含量变化密切相关 (P <0 0 1)。结论 :NO和IL - 2、TNF -α在人工晶体植入术后眼内炎症反应中可能均起重要的作用。
Objective: To investigate the relationship between interleukin - 2 (IL - 2), tumor necrosis factor - α (TNF - α) and nitric oxide (NO) in aqueous humor after intraocular lens implantation. Methods: New Zealand white rabbits were randomly divided into three groups: (1) normal control group, (2) extracapsular cataract extraction group (ECCE), (3) extracapsular cataract extraction + intraocular lens implantation group ECCE + IOL). At the same time, the levels of IL - 2, TNF - α and the content of NO2 - / NO3 - in aqueous humor were measured at 0, 1, 3, 7, 14 and 30 days after operation. Results: (1) The levels of IL - 2, TNF - α and NO2 - / NO3 - in aqueous humor of ECCE + IOL group after 1 ~ 14 days were significantly higher than that of ECCE group and control group, which peaked at 3-7 days after operation. (2) The changes of IL - 2, TNF - α and NO2 - / NO3 - contents in aqueous humor were the same in all groups. The levels of IL - 2 and TNF - α in aqueous humor were closely related to the changes of NO content <0 0 1). Conclusion: Both NO, IL - 2 and TNF - α may play an important role in intraocular inflammation after intraocular lens implantation.