论文部分内容阅读
目的观察左乙拉西坦(LEV)和卡马西平(CBZ)单药治疗对癫痫部分性发作患儿脑电图的影响。方法选取符合诊断标准的癫痫患儿80例,随机分2组,LEV组和CBZ组各40例,于治疗前及治疗后每3个月复查一次脑电图,观察治疗前后脑电图的变化。结果治疗后两组间临床发作控制比较无差异(P=0.68),治疗后两组间脑电图痫样放电比较,CBZ组痫样放电完全消失7例,减少50%以上7例,减少25%-49%11例,无变化8例,增加7例,LEV组痫样放电完全消失21例,减少50%以上7例,减少25%-49%6例,无变化3例,增加3例。两组差异有统计学意义(P=0.001)。结论 LEV作为一种新型抗癫痫药物,在改善脑电图方面具有明显的优势,在治疗小儿癫痫部分性发作方面具有广大的应用前景。
Objective To observe the effects of monotherapy with levetiracetam (LEV) and carbamazepine (CBZ) on the EEG in children with partial epilepsy. Methods Eighty children with epilepsy who met the diagnostic criteria were randomly divided into 2 groups, 40 cases in LEV group and CBZ group. The changes of EEG before and after treatment were observed before treatment and every 3 months after treatment. . Results There was no difference in the control of clinical seizure between the two groups after treatment (P = 0.68). After the treatment, EEG epileptiform discharge was compared between the two groups. In the CBZ group, epileptiform discharge completely disappeared in 7 cases, decreased by 50% or more in 7 cases and decreased by 25% % -49% in 11 cases, no change in 8 cases, an increase of 7 cases, LEV group disappeared in 21 cases of epileptic discharge completely reduced by 50% or more in 7 cases, 25% -49% reduction in 6 cases, no change in 3 cases, an increase of 3 cases . The difference between the two groups was statistically significant (P = 0.001). Conclusions LEV, as a novel anti-epileptic drug, has obvious advantages in improving EEG and has broad application prospects in the treatment of partial seizures in children.