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目的探讨癫痫发作与假性发作患者在发作后24小时内血清神经元特异性烯醇化酶(NSE)的变化及意义。方法用放射免疫法测定46例癫痫发作患者和43例假性发作患者的血清NSE水平,并与50例健康人作比较。结果46例癫痫发作者血清NSE水平为(15.8±3.45)μg/ml;43例假性发作者血清NSE水平为(8.03±2.76)μg/ml;50例健康人血清NSE水平为(8.24±2.86)μg/ml。癫痫发作组与假性发作组以及健康对照组的检测结果比较,差异有统计学意义(P<0.01),假性发作组与正常对照组比较差异无统计学意义。结论癫痫发作后存在脑组织神经元损害,测定血清NSE有助于癫痫发作与假性发作者之间的鉴别。
Objective To investigate the changes and significance of serum neuron-specific enolase (NSE) within 24 hours after the onset of seizures in patients with seizures and pseudo-seizures. Methods Serum NSE levels were measured by radioimmunoassay in 46 seizures and 43 cases of pseudo-seizures and compared with 50 healthy subjects. Results Serum levels of NSE in 46 seizures were (15.8 ± 3.45) μg / ml; serum NSE level was (8.03 ± 2.76) μg / ml in 43 cases of pseudo-seizure; serum level of NSE was (8.24 ± 2.86) μg / ml. There was significant difference between the seizure group and the pseudo-seizure group and the healthy control group (P <0.01). There was no significant difference between the pseudo-seizure group and the normal control group. Conclusion There is neuronal damage in brain tissue after epileptic seizure. Determining serum NSE can be used to distinguish between seizure and pseudo-seizure.