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目的观察美沙拉嗪联合灌肠液治疗溃疡性结肠炎的临床治疗疗效。方法选取2013年2月-2015年9月医院收治的溃疡性结肠炎患者168例,随机分为观察组与对照组各84例。观察组予美沙拉嗪联合灌肠液治疗,对照组仅予美沙拉嗪治疗,比较2组治疗前后肠镜检查结果、治疗总有效率及不良反应发生状况。结果结肠镜检查结果示观察组治疗后总缓解率为100.0%显著高于对照组的89.3%,差异有统计学意义(P<0.05)。观察组总有效率为92.5%显著高于对照组的72.6%,差异有统计学意义(P<0.05)。观察组不良反应发生率为10.7%,与对照组的17.9%比较差异无统计学意义(P>0.05)。结论美沙拉嗪联合灌肠液治疗溃疡性结肠炎临床治疗效果显著优于单纯口服美沙拉嗪,且有助于复发率的降低,值得临床推广应用。
Objective To observe the curative effect of mesalazine combined with enema in the treatment of ulcerative colitis. Methods A total of 168 patients with ulcerative colitis admitted to our hospital from February 2013 to September 2015 were randomly divided into observation group (84 cases) and control group (84 cases). The observation group was treated with mesalazine combined with enema. The control group was treated with mesalazine only. The results of colonoscopy before and after treatment were compared between the two groups. The total effective rate and incidence of adverse reactions were compared. Results The results of colonoscopy showed that the total remission rate of observation group after treatment was 100.0%, which was significantly higher than that of the control group (89.3%), the difference was statistically significant (P <0.05). The total effective rate in the observation group was 92.5%, which was significantly higher than that in the control group (72.6%), the difference was statistically significant (P <0.05). The incidence of adverse reactions in the observation group was 10.7%, which was no significant difference compared with 17.9% in the control group (P> 0.05). Conclusion Mesalazine combined with enema in the treatment of ulcerative colitis clinical efficacy was significantly better than the simple oral mesalamine, and help reduce the recurrence rate, worthy of clinical application.