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目的:探讨对新生儿缺氧缺血性脑病(HIE)进行早期行为干预的意义。方法:将148例HIE足月儿随机分为干预组78例和对照组70例,均给予早期综合治疗,包括药物治疗(神经节苷脂静脉滴注)、高压氧疗、人工抚触;干预组在早期综合治疗基础上同时进行早期行为干预,包括早期行为训练及水疗、婴儿操等综合训练。在患儿1、3、6、12、24月龄时对其进行智力发育和心理运动发育评估。结果:干预组患儿6月龄之后的智力发育指数(MDI)、心理运动发育指数(PDI)均高于对照组(P<0.05)。干预组后遗症(脑瘫、智能发育迟滞等)发生率为6.41%(5/78),低于对照组的15.71%(11/70)。结论:在早期综合治疗基础上对HIE患儿进行早期行为干预可明显改善患儿智力、运动发育,减少脑瘫、智能发育迟滞等后遗症的发生,改善预后。
Objective: To explore the significance of early behavioral intervention in neonatal hypoxic-ischemic encephalopathy (HIE). Methods: A total of 148 HIE term infants were randomly divided into intervention group (n = 78) and control group (n = 70). All of them were given early comprehensive treatment including drug treatment (ganglioside intravenous drip), hyperbaric oxygen therapy, Group based on the early comprehensive treatment of early behavioral interventions at the same time, including early behavioral training and spa, infants and other comprehensive training. Children were assessed for mental development and psychomotor development at 1, 3, 6, 12, and 24 months of age. Results: The mental development index (MDI) and psychological development index (PDI) of children in intervention group after 6 months old were higher than those in control group (P <0.05). The incidence of sequelae (cerebral palsy, delayed mental retardation) in the intervention group was 6.41% (5/78), which was lower than that in the control group (15.71%, 11/70). Conclusion: Early behavioral intervention in children with HIE based on early comprehensive treatment can significantly improve children’s mental and physical development, reduce the occurrence of sequelae such as cerebral palsy and delayed mental retardation, and improve prognosis.