论文部分内容阅读
目的:观察急性心肌梗死(AMI)患者血清胎盘生长因子(PlGF)及超敏C-反应蛋白的动态变化及意义。方法:测定60例AMI患者(AMI组)发病第12小时、第3天、第7天血清中PlGF及超敏C-反应蛋白水平,并于第14天行超声心动图检测。另选40例健康体检者为正常对照组。PlGF采用酶联免疫吸附双抗体夹心法原理定量测定。结果:AMI组发病第12小时、第3天PlGF均显著高于正常对照组,差异有统计学意义(P<0.05),第7天与正常对照组相比差异无统计学意义(P>0.05);第12小时、第3天、第7天超敏C-反应蛋白均显著高于正常对照组,差异有统计学意义(P<0.05);血清PlGF与左心室射血分数呈显著负相关(r=-0.654;P<0.01),与左心室舒张末期容积和左心室舒张末期内径均呈显著正相关(r=0.845,0.684;P<0.01)。结论:AMI时患者血清PlGF水平显著增高,AMI后第3天达到相对高值,第7天降至正常人群水平。PlGF水平可能影响左心室重构。
Objective: To observe the dynamic changes of serum placental growth factor (PlGF) and hypersensitive C-reactive protein in patients with acute myocardial infarction (AMI). Methods: The serum levels of PlGF and hypersensitive C-reactive protein were measured in 12 AMI, AMI, AMI, AMI and AMI patients on the 12th, the 3rd day and the 7th day respectively. Echocardiography was performed on the 14th day. Another 40 healthy subjects were normal control group. PlGF enzyme-linked immunosorbent double antibody sandwich method for quantitative determination. Results: In the AMI group, on the 12th day and the 3rd day, PlGF was significantly higher than that of the normal control group (P <0.05), and there was no significant difference between the 7th day and the normal control group (P> 0.05 ). The levels of hypersensitive C-reactive protein in the 12th, 3rd and 7th day were significantly higher than those in the normal control group (P <0.05). There was a significant negative correlation between serum PlGF and left ventricular ejection fraction (r = -0.654; P <0.01), and positively correlated with left ventricular end diastolic volume and left ventricular end diastolic diameter (r = 0.845,0.684; P <0.01). Conclusions: The level of PlGF in patients with AMI was significantly higher than that in AMI patients. The AMI patients reached the relatively high value on the third day and dropped to the normal level on the seventh day. PlGF levels may affect left ventricular remodeling.