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超氧化物歧化酶(SOD)在机体中的含量和活性与疾病的关系已得到广泛研究。在胃肠道肿瘤、非特异性炎症、溃疡等疾病的患者血液中SOD活性有显著减少,但胃肠道、食管之肿瘤组织及炎症粘膜组织内SOD活性的研究,少有报道。本文测定食管癌、胃癌、慢性萎缩性胃炎、慢性浅表性胃炎、胃溃疡、十二指肠球部溃疡等病变粘膜组织中的SOD总活性,并将其与非病变粘膜组织中的SOD总活性作比较,以进一步揭示粘膜组织内的SOD变化与疾病的关系。 1 对象和方法 1.1 对象 选择我院内镜检查中发现的胃癌24例,食管癌12例,胃溃疡31例,十二指肠球部溃疡48例,慢性浅表性胃炎69例,慢性萎缩性胃炎27例,共211例患者。
The relationship between the content and activity of superoxide dismutase (SOD) in the body and the disease has been extensively studied. In patients with gastrointestinal cancer, nonspecific inflammation, ulcers and other diseases, SOD activity is significantly reduced, but the gastrointestinal tract, esophageal tumor tissue and inflammatory mucosal SOD activity has rarely been reported. In this paper, the determination of esophageal cancer, gastric cancer, chronic atrophic gastritis, chronic superficial gastritis, gastric ulcer, duodenal ulcer lesions such as mucosal SOD activity and its non-diseased mucosa in the total SOD Activity compared to further reveal the changes in mucosal SOD and the relationship between disease. 1 Subjects and methods 1.1 Subjects selected in our hospital found 24 cases of gastric cancer, esophageal cancer in 12 cases, 31 cases of gastric ulcer in 48 cases, chronic superficial gastritis in 69 cases, chronic atrophic Gastritis in 27 cases, a total of 211 patients.