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某些药物如阿司匹林、催眠药、抗恶心药、琥珀酰胆硷和筒箭毒硷等只需一次给药,但大多数情况下,药物常需连续多次给药才能达到一定的治疗效果。在使用洋地黄时,首次量或头几次剂量要比维持量为大,以便迅速产生有治疗作用的血药浓度或组织药浓度,此后再隔一定间期给以维持量,以保持有效浓度。对维持量或给药间隔时间的选择不当,可导致治疗无效或药物蓄积。因此拟订给药方案(Dosage Regimens)直接关系到合理用药和保证临床效果。多数药物为每天给药6次、3次、2次或1次。给药次数的确定有赖于若干因素,其
Some drugs such as aspirin, hypnotics, anti-nausea drugs, succinylcholine and myostatin and other just a single administration, but in most cases, the drug often require multiple administrations to achieve a certain therapeutic effect. In the use of digitalis, the first dose or the first few doses than the maintenance dose is large, in order to quickly produce a therapeutic blood concentration or tissue concentration, then a certain interval to maintain the volume to maintain the effective concentration . Improper selection of maintenance doses or dosing intervals can result in ineffective treatment or drug accumulation. Therefore, the development of dosing regimens (Dosage Regimens) is directly related to the rational use of drugs and to ensure clinical effectiveness. Most drugs are given 6 times daily, 3 times, 2 times or once. The number of dosing depends on several factors