ｐ１６基因是一种肿瘤抑制基因，其编码产物为ＣＤＫ４的抑制物，在细胞增殖周期中起负调节作用。ｐ１６基因的突变和缺失会丧失对细胞周期的调控，导致细胞异常增生，最终形成肿瘤。ｐ１６基因与脑肿瘤关系密切，脑胶质瘤细胞株与原发性脑胶质瘤及恶性胶质瘤中ｐ１６基因缺失率较高；在非星形胶质细胞瘤中很少有ｐ１６基因的改变。ｐ１６基因的失活机理主要有基因突变；基因转录和翻译异常；可能与Ｒｂ基因改变或ＣＤＫ４增加有关等方面 The p16 gene is a tumor suppressor gene whose encoded product is an inhibitor of CDK4 and plays a negative regulatory role in the cell cycle. Mutations and deletions of the p16 gene lose their regulation of the cell cycle, resulting in abnormal cell proliferation and tumor formation. The p16 gene is closely related to brain tumors. The rate of p16 gene deletion in glioma cell lines, primary glioma and glioblastoma is high. In non-astrocytoma, there is little p16 gene change. The mechanism of inactivation of p16 gene mainly includes gene mutation, gene transcription and translation abnormalities, may be related to the change of Rb gene or the increase of CDK4