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目的探讨肝癌介入治疗所致肝损害的发病因素,以减少和预防肝功能受损的发生。方法选择2007年1月至2011年12月收治的肝癌介入患者300例,观察肝损害的发病情况,同时对发病因素进行统计分析。结果共有42例患者发生肝损害,发生率为14.0%。单因素分析结果显示,年龄、治疗前血清转氨酶升高、饮酒史、既往肝炎病史、服用保肝药物、高血压病史与肝损害有相关性(P<0.05)。多因素分析结果显示,治疗前血清转氨酶升高、既往肝炎病史、年龄为主要的危险因素(P<0.05)。结论治疗前血清转氨酶升高、既往肝炎病史、年龄是肝癌介入治疗后肝功能受损的重要危险因素,对此应当提高重视,以减少和预防肝功能受损的发生。
Objective To investigate the incidence of liver damage caused by interventional treatment of liver cancer in order to reduce and prevent the occurrence of impaired liver function. Methods From January 2007 to December 2011, 300 patients with liver cancer who were admitted to our hospital were enrolled in this study. The incidence of liver damage was observed, and the incidence of the disease was statistically analyzed. Results A total of 42 patients developed liver damage, the incidence was 14.0%. Univariate analysis showed that age, pretreatment serum aminotransferase, history of alcohol consumption, previous history of hepatitis, taking hepatoprotective drugs, history of hypertension and liver damage were related (P <0.05). Multivariate analysis showed that before treatment serum aminotransferase increased, history of previous hepatitis and age as the main risk factors (P <0.05). Conclusions Serum aminotransferase elevated before treatment, history of previous hepatitis, and age are important risk factors of hepatic dysfunction after interventional treatment of hepatocellular carcinoma. Therefore, attention should be paid to reduce and prevent the occurrence of hepatic dysfunction.