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背景与目的:研究高氡暴露地区人群中CYP1A1基因多态性与肺癌易感性的关系。材料与方法:采用病例-对照研究方法,以基因体外扩增限制性片段长度多态性分析(RFLP-PCR)技术,对高氡暴露地区53例肺癌患者和72例对照人员进行了代谢酶CYP1A1(MSPⅠ)基因多态性检测,并分析了不同人群中该基因多态性与肺癌发病风险的关系。结果:在氡暴露地区CYP1A1(MSPⅠ)基因杂合型人群的肺癌发病的OR(优势比)值为1.03(95%可信限0.468～2.30)。分层分析:有效剂量<50mSv的人群中CYP1A1(MSPⅠ)基因杂合型的肺癌发病风险增至4.29倍(95%可信限0.582～88.2),年龄在40～59岁人群中CYP1A1(MSPⅠ)基因杂合型的肺癌发病风险是野生型的1.22倍(95%可信限0.145～3.65)。结论:CYP1A1(MSPⅠ)基因多态性与肺癌易感性无显著关联,但CYP1A1(MSPⅠ)基因杂合型对观察人群的肺鳞癌发病风险、有效剂量<50mSv的人群肺癌发病风险、非吸烟人群的肺癌发病风险和40～59岁人群肺癌发病风险均有增高的趋势。
BACKGROUND & AIM: To investigate the association between CYP1A1 gene polymorphism and susceptibility to lung cancer in population with high radon exposure. MATERIALS AND METHODS: A total of 53 lung cancer patients and 72 control subjects with high radon exposure were enrolled in this study. The metabolic enzymes CYP1A1 (MSPⅠ) gene polymorphism and to analyze the relationship between the gene polymorphism and the risk of lung cancer in different populations. RESULTS: OR (odds ratio) was 1.03 for patients with heterozygous CYP1A1 (MSPI) heterozygous population exposed to radon (1.05% confidence interval, 0.468-2.30). Stratification analysis showed that the risk of heterozygous CYP1A1 (MSPⅠ) heterozygous lung cancer increased to 4.29 times (95% confidence interval 0.582 ~ 88.2) in the population with effective dose <50mSv, CYP1A1 (MSPⅠ) Gene heterozygous lung cancer risk of 1.22 times the wild-type (95% confidence limit 0.145 ~ 3.65). CONCLUSION: CYP1A1 (MSPⅠ) gene polymorphism is not associated with lung cancer susceptibility. However, heterozygous CYP1A1 (MSPⅠ) gene may be associated with the risk of lung squamous cell carcinoma, the risk of lung cancer in population with effective dose <50mSv, Of the risk of lung cancer and 40 to 59-year-old population have an increasing trend of lung cancer risk.