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为研究日本血吸虫ＳｊＲ４７ 组分抗原诱导的抗虫卵肉芽肿保护性免疫机制，探讨细胞因子ＴＮＦα及ＩＬ８与ＳｊＲ４７ 诱导的保护性免疫力之间的关系，本研究用纯化的ＳｊＲ４７ 组分抗原免疫ＢＡＬＢ／ｃ 小鼠，攻击感染后０～１２ｗｋ 测定血清ＴＮＦα和ＩＬ８ 水平的动态变化。实验结果表明，ＳｊＲ４７ 可显著影响宿主ＴＮＦα水平的表达，推测ＳｊＲ４７ 诱导的抗虫卵肉芽肿保护性免疫机制可能与宿主体内ＴＮＦα水平的变化有关。
In order to study the protective immunity mechanism of insect-resistant egg granuloma induced by antigen of SjR47 of Schistosoma japonicum and to explore the relationship between TNFα and IL8 and the protective immunity induced by SjR47, we used the purified SjR47 group Divided antigen BALB / c mice immunized to 0 to 12 weeks after challenge to measure the dynamic changes of serum TNF α and IL 8 levels. Experimental results show that, SjR47 can significantly affect the expression of TNF @ level of the host speculated that SjR47-induced protective immunity of insect-resistant egg granulomas may be related to changes in the host body TNF @ level.