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采用高效液相色谱法测定脑梗塞患者脑脊液中的 15种氨基酸 ,同时测定脑梗塞体积 ,并对神经功能缺损程度进行评分。结果表明 :脑梗塞组天冬氨酸、谷氨酸均较对照组显著性增高 (分别为P <0 .0 1,P <0 .0 5 ) ;γ 氨基丁酸较对照组显著降低 (P <0 .0 5 ) ,此外 ,丙氨酸和亮氨酸较对照组亦明显升高 (分别为P <0 .0 1,P <0 .0 5 )。天冬氨酸、谷氨酸水平与脑梗塞体积呈正相关 (分别r天 =0 .5 6 ,P <0 .0 5 ;r谷 =0 .5 2 ,P <0 .0 5 ) ;所有氨基酸与神经功能缺损程度相关性不明显。本文结果提示 ,兴奋性氨基酸在脑梗塞中参与了神经损害作用 ,而抑制性氨基酸是否具有保护作用值得进一步研究
Fifteen kinds of amino acids in cerebrospinal fluid of patients with cerebral infarction were measured by high performance liquid chromatography (HPLC). The volume of cerebral infarction was also measured. The degree of neurological deficit was also scored. The results showed that aspartate and glutamate in cerebral infarction group were significantly higher than those in control group (P <0.01, P <0.05), while γ-aminobutyric acid <0. 05). In addition, alanine and leucine also significantly increased compared with the control group (P <0.01, P <0.05, respectively). The levels of aspartate and glutamate were positively correlated with the volume of cerebral infarction (r days = 0.56, P <0.05, r = 0.25, P <0.05); all amino acids Correlation with the degree of neurological deficit is not obvious. The results suggest that excitatory amino acids are involved in the role of nerve damage in cerebral infarction, and whether the inhibitory amino acids have protective effect deserves further study