结节病是一种慢性多系统性疾病。其特征是受损器官有单核细胞和免疫效应细胞聚集,正常组织的结构可发生紊乱,但无干酪性肉芽肿。大多数器官可受损,其中肺最易受损,且是死亡的原因。在肺部所有的部位都可侵及,但导致肺功能紊乱主要由于下呼吸道,特别是肺泡结构的累及,可有大量单核效应细胞(通常称之为结节病肺泡炎),肺泡壁形成肉芽肿,间隔变厚伴上皮细胞、内皮细胞和间质细胞正常排列的紊乱,在某些患者还存在间质纤 Sarcoidosis is a chronic, multisystem disease. It is characterized by damaged organs mononuclear cells and immune effector cells aggregated, the structure of normal tissue disorders can occur, but no case of granuloma. Most organs can be damaged, with the lungs the most vulnerable, and the cause of death. In all parts of the lung can be invading, but lead to pulmonary dysfunction mainly due to the lower respiratory tract, especially the involvement of alveolar structure, there may be a large number of mononuclear effector cells (commonly known as sarcoidosis alveolitis), alveolar wall formation Granulomas, thickening of the interval with normal epithelial cells, endothelial cells and interstitial cells disorder, in some patients also exist interstitial fiber