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目的 建立5-氟脲嘧啶(5-Fu)所致贫血的大鼠模型。方法 单次由尾静脉注射5-Fu 150 mg/kg。结果 血红蛋白浓度和网织红细胞数目明显减少,血清红细胞生成素水平明显增加。结论 150mg/kg5-Fu可诱导大鼠贫血模型。
Objective To establish a rat model of anemia induced by 5-fluorouracil (5-Fu). Methods A single injection of 5-Fu 150 mg / kg from the tail vein. Results The hemoglobin concentration and the number of reticulocytes decreased significantly, the level of serum erythropoietin increased significantly. Conclusion 150mg / kg 5-Fu can induce rat anemia model.