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目的探讨抗生素、抗病毒药、免疫调节剂及营养支持的联合使用在严重急性呼吸综合征(SARS)患者治疗中的作用。方法分析太原市定点医院304例住院确诊SARS病历,探讨四种不同治疗方案对SARS患者的临床疗效。结果接受四种方案治疗后患者的住院时间差异有统计学意义(F=11.107,P<0.01),方案D较方案A、B、C的平均住院时间短;四种方案体温恢复正常的时间差异有统计学意义(F=4.794,P=0.003),方案A比其他三种方案的体温恢复正常的时间长;接受四种方案治疗的SARS患者治疗结果差异有统计学意义(确切概率P=0.001),方案A比其他三种方案的病死率高。结论抗生素、抗病毒药联合免疫调节剂或营养支持的疗效优于单独使用抗生素和抗病毒药。
Objective To investigate the role of antibiotics, antivirals, immunomodulators and nutritional support in the treatment of patients with severe acute respiratory syndrome (SARS). Methods 304 hospitalized cases of SARS in Dingyuan Hospital of Taiyuan were analyzed, and the clinical effects of four different treatment regimens on patients with SARS were analyzed. Results There was significant difference in hospitalization time between the four treatment regimens (F = 11.107, P <0.01). The average length of hospital stay in case D was shorter than that in cases A, B and C. The time difference between the four regimens (F = 4.794, P = 0.003). The duration of body temperature recovery in protocol A was longer than that of the other three protocols. The differences in the treatment outcomes among the four treatment regimens were statistically significant (exact P = 0.001 ), Scheme A has a higher case fatality rate than the other three schemes. Conclusions Antibiotics, antiviral agents combined with immunomodulators or nutritional support are superior to antibiotics and antiviral drugs alone.