论文部分内容阅读
血管内皮生长因子（VEGF）是一种特异性刺激血管内皮细胞增殖和新生血管形成的生长因子,是最直接的血管内皮细胞促分裂素,与血管内皮生长因子受体（VEGFR）结合而发挥各项功能。在视网膜细胞、色素上皮细胞、表皮细胞、M(?)ller细胞内均有VEGFR表达。缺氧可上调其基因表达,直接造成视网膜新生血管形成及增生性玻璃体视网膜病变。对VEGFR结构、功能、与新生血管的关系,VEGFR表达增高所导致的病理变化,VEGFR高表达的调节因素,如何抑制VEGFR阻断VEGF/VEGFR信号传导途径抑制VEGF作用等方面进行了较为全面的综述。
Vascular endothelial growth factor (VEGF) is a growth factor that specifically stimulates the proliferation and angiogenesis of vascular endothelial cells. It is the most direct vascular endothelial cell mitogen and binds to vascular endothelial growth factor receptor (VEGFR) Item function. In retinal cells, pigment epithelial cells, epidermal cells, M (?) Ller cells have VEGFR expression. Hypoxia can up-regulate its gene expression, directly causing retinal neovascularization and proliferative vitreoretinopathy. This review summarizes the relationship between the structure and function of VEGFR and neovascularization, the pathological changes caused by the increase of VEGFR expression, the regulatory factors of high expression of VEGFR, and how to inhibit VEGFR by blocking VEGF / VEGFR signal transduction pathway. .