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目的:检测不同冠心病患者血清激活素A水平,观察其与冠心病危险程度的关系,探讨其临床意义。方法:90例经冠状动脉造影证实的冠心病患者分为稳定心绞痛组和急性冠状动脉综合征组(42例),同期健康体检者40例为对照组。检测各组血清激活素A、C反应蛋白、白介素-6水平,并进行比较。结果:急性冠状动脉综合征组、稳定心绞痛组血清激活素A浓度分别为(657.48±193.67)pg/mL,(423.75±169.36)pg/mL,较对照组(127.94±61.73)pg/mL升高(P<0.05)。且急性冠状动脉综合征组高于稳定心绞痛组(P<0.05)。急性冠状动脉综合征组、稳定心绞痛组C反应蛋白、白介素-6浓度升高,与对照组比较差异均有统计学意义(P<0.05),急性冠状动脉综合征组亦高于稳定心绞痛组(P<0.05)。结论:与2种重要的炎症因子C反应蛋白和白介素-6相似,冠心病患者血清中激活素A水平增高,且冠状动脉斑块越不稳定其增高水平越明显。激活素A可能通过调节斑块的炎症反应,参与动脉粥样硬化的发生、发展过程,有望成为冠心病斑块稳定性的良好预测指标之一。
Objective: To detect the level of serum activin-A in patients with coronary heart disease and to observe its relationship with the risk of coronary heart disease and to explore its clinical significance. Methods: Ninety patients with coronary heart disease confirmed by coronary angiography were divided into two groups: stable angina pectoris group and acute coronary syndrome group (n = 42). Forty patients with normal physical examination in the same period served as the control group. Serum levels of activin A, C-reactive protein and interleukin-6 were measured and compared. Results: Serum levels of activin A in patients with acute coronary syndrome and stable angina were (657.48 ± 193.67) pg / mL and (423.75 ± 169.36) pg / mL, respectively, which were significantly higher than those in the control group (127.94 ± 61.73) pg / mL (P <0.05). Acute coronary syndrome group was higher than that of stable angina group (P <0.05). The levels of C-reactive protein and interleukin-6 in patients with acute coronary syndrome and stable angina were significantly higher than those in control (P <0.05), and those in patients with acute coronary syndrome were also higher than those in patients with stable angina P <0.05). CONCLUSION: Similar to the two important inflammatory factors C-reactive protein and interleukin-6, the serum level of activin-A in patients with coronary artery disease is elevated, and the more unstable the coronary plaque is, the more obvious the level is. Activin A may be one of the good predictors of plaque stability in coronary heart disease by regulating the inflammatory reaction of plaque and participating in the occurrence and development of atherosclerosis.