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用国产胰岛素在54只新西兰大耳白家兔体内观察其经眼给药后药物代谢动力学特征。结果表明,分子量约为6000的胰岛素滴眼后能有效地进入血液循环。体内药物动力学为开放性一级动力学—房室模型。消除半衰期为40～60min,与静脉注射相比,消除半衰期明显延长。达峰时间为20～50min。金属络合剂EDTA对胰岛素的经眼吸收有促进作用。经眼给药后体内药物的浓度呈现出剂量依赖性。
54 domestic New Zealand white rabbits with domestic insulin were observed for their pharmacokinetic characteristics after ocular administration. The results show that the molecular weight of about 6,000 after insulin drops into the blood circulation effectively. In vivo pharmacokinetics are open first order kinetics - atrioventricular model. Elimination half-life of 40 ~ 60min, compared with intravenous injection, elimination half-life was significantly prolonged. Peak time is 20 ~ 50min. Metal complexing agent EDTA can promote the absorption of insulin by eyes. The concentration of drug in the body after dose was dose-dependent.