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通过异烟肼和4-N,N-二羟乙基苯甲醛来合成一种席夫碱及其锡配合物,并通过核磁、元素分析以及X-射线单晶衍射来进行结构表征。该平面构型的席夫碱采取二齿配位模式,其中的-C=N-在配位后由反式变为顺式。晶体结构数据以及荧光光谱中的显著红移现象表明锡配合物中的π-共轭体系通过配位反应得以延展。体外细胞毒性数据表明,席夫碱配体及其锡配合物对于A-549,MCF-7和Hela等肿瘤细胞的生长抑制活性要强于顺铂。还通过紫外可见光谱及荧光光谱初步研究了两种化合物与DNA的相互作用,结果表明锡配合物可能通过共价结合来导致DNA双螺旋链变形,而席夫碱分子中的氢键效应及其长平面结构可能会阻碍其嵌入DNA双螺旋链。
A Schiff base and its tin complex were synthesized by isoniazid and 4-N, N-dihydroxyethylbenzaldehyde and characterized by NMR, elemental analysis and X-ray single crystal diffraction. The Schiff base of the planar configuration adopts a bidentate coordination mode in which -C = N- changes from trans to cis after coordination. The crystal structure data and the significant red shift phenomenon in the fluorescence spectrum show that the π-conjugated system in the tin complex is extended by the coordination reaction. In vitro cytotoxicity data show that Schiff base ligand and its tin complexes for the A-549, MCF-7 and Hela other tumor growth inhibitory activity than cisplatin. The interaction between the two compounds and DNA was also studied by UV-Vis and fluorescence spectroscopy. The results show that the tin complexes may cause DNA double helix chain to be deformed through covalent bonding. However, the hydrogen bonding effect between Schiff base and its Long planar structures may hinder their insertion into the DNA double helix.