环亮氨酸(80mg/kg)灌喂感染伯氏疟原虫小鼠5d,完全制止原虫生长。体外培养的恶性疟原虫(P.f)与环亮氨酸(1.5×10~(-2)M)接触3d,红内期原虫失去侵入新红细胞的能力,变异虫达90％。恶性疟原虫在体外与环亮氨酸培养30h,[~3H]次黄嘌呤掺入感染红细胞的量被抑制52～58％,掺入核酸中的量较对照减少79％;[~(14)C]甲硫氨酸的掺入被抑制30％,而其生成精脒的量被抑制50％。 Cyclic leucine (80 mg / kg) was infused to mice infected with P. berghei for 5 days to completely stop the growth of protozoa. Plasmodium falciparum (P.f) cultured in vitro was exposed to cyclic leucine (1.5 × 10 -2 M) for 3 days. The protozoa lost the ability to invade new erythrocytes and the mutants reached 90%. Plasmodium falciparum cultured in vitro and cyclic leucine for 30h, [~ 3H] hypoxanthine incorporation of infected red blood cells was inhibited 52 ~ 58%, the amount of nucleic acid incorporation was reduced by 79%; [~ (14) C] methionine is inhibited by 30%, and the amount of spermidine produced is inhibited by 50%.