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肝X受体(liver X receptor,LXR)是细胞核受体超家族的成员之一,也曾被称为孤儿受体。现已经明确LXR包括LXRα(NR1H3)和LXRβ(NR1H2)两种同源亚型。研究发现,LXR与甾醇调节元件结合蛋白(SREBP-1)、氧化修饰低密度脂蛋白(oxLDL)、一氧化氮(NO)、基质金属蛋白酶(MMPs)、Endoglin(CD105)、人绒毛膜促性腺激素(hCG)等存在联系,而这些因素又参与子痫前期的发病,证实了LXR与脂类的代谢、血管内皮的损伤、滋养细胞的增殖和侵袭等有关。因此LXR表达异常可能在子痫前期的发生发展中起重要作用。
Liver X receptor (LXR) is a member of nuclear receptor superfamily, also known as orphan receptor. It has now been clarified that LXR includes two homologs of LXRα (NR1H3) and LXRβ (NR1H2). We found that LXR interacts with SREBP-1, oxLDL, NO, MMPs, Endoglin (CD105), human chorionic gonadotropin Hormone (hCG), etc., and these factors are involved in the pathogenesis of preeclampsia, confirming the LXR and lipid metabolism, vascular endothelial damage, trophoblast proliferation and invasion and so on. Therefore, abnormal expression of LXR may play an important role in the development of preeclampsia.