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目的观察巯亚硝基卡托普利（ＣａｐＮＯ）对不同类型高血压大鼠血压的影响并与卡托普利（Ｃａｐ）相比较。方法记录麻醉和清醒大鼠颈动脉血压。结果ＣａｐＮＯ对正常大鼠、急性二肾一夹高血压大鼠；自发性高血压大鼠均表现明显的剂量依赖性的降压效应，且强于同剂量Ｃａｐ。其特点表现早、快、强而持久，加速降压速率，延长降压时程、增大降压曲线面积，尤其对舒张压的降压影响更显著于对收缩压的影响，上述作用在高血压动物的表现均较正常血压动物更明显。结论ＣａｐＮＯ抗高血压作用优于Ｃａｐ，其对舒张压的作用强于对收缩压的影响。
Objective To observe the effects of Capn on blood pressure in different types of hypertensive rats and to compare with captopril (Cap). Methods Anesthetic and awake rat carotid blood pressure was recorded. Results CapNO had a dose-dependent antihypertensive effect on normal rats and acute two-kidney-one-clip hypertensive rats, and spontaneous hypertensive rats were stronger than the same dose Cap. The characteristics of early, fast, strong and lasting, accelerated buck rate, prolong the duration of antihypertensive, increasing the area of antihypertensive curve, especially for the antihypertensive effect of diastolic blood pressure more pronounced on the impact of systolic blood pressure, the role of high Blood pressure animal performance than normal blood pressure animal more obvious. Conclusion CapNO is superior to Cap in its antihypertensive effect and its effect on diastolic blood pressure is stronger than on systolic blood pressure.