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异名妥克律、Apx、W36095、Tonacard 化学名 2-氨基丙酰-2′,6′-二甲苯胺药效分类抗心率失常药开发单位 (瑞典)Astra 上市厂商 (英)Astra 1981年10月首次报道 Proc Jap Soc Hematol-Coagulation Res 药理本品为利多卡因的伯胺类似物。其电生理性质与利多卡因相似,有较好的抗心律失常作用,而对传导系统影响较小。本品不抑制左心室功能,可安全地用于左心室功能不良的病人。本品与利多卡因不同之处为口服具有较高的生物利用度,不但可供静注,而且适于口服治疗。此外还具有作用持久等优点。对急性心肌梗塞或曾用β-阻断剂治疗的室性心律失常患者,在治疗的血浆浓
Synonyms Chartres, Apx, W36095, Tonacard Chemical Name 2-Aminopropionyl-2 ’, 6’-Dimethylaniline Pharmacodynamic Category Antiarrhythmic Drug Developers (Sweden) Astra Listed Company Astra 1981 10 First reported in April Proc Jap Soc Hematol-Coagulation Res Pharmacology This product is a primary amine analog of lidocaine. Its electrophysiological properties similar to lidocaine, have better anti-arrhythmic effect, and less impact on the conduction system. This product does not inhibit left ventricular function, can be safely used for patients with left ventricular dysfunction. This product is different from lidocaine oral bioavailability, not only for intravenous injection, but also for oral treatment. In addition it has the advantage of lasting effect. In patients with acute myocardial infarction or ventricular arrhythmias who have been treated with beta-blockers,