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将１，４－二（苯并唑－１，３－基－２）苯（ＢＢＯＢ）包埋在增塑的聚氯乙烯膜中，研制了一种新的荧光猝灭型甲硝唑光纤传感器．猝灭机制包括甲硝唑的初级内滤效应和甲硝唑与ＢＢＯＢ形成电荷转移复合物两种作用．传感器可逆性好，响应时间小于３０ｓ，响应线性范围是４．００×１０－６～１．００×１０－４ｍｏｌ／Ｌ，检测限为１．００×１０－６ｍｏｌ／Ｌ，对１．００×１０－４ｍｏｌ／Ｌ甲硝唑的相对偏差为０．８２％（ｎ＝１０）．常见的无机离子、药物不影响甲硝唑的测定，对商品制剂中甲硝唑的测定结果与药典法一致．
A novel fluorescence quenching type A (BPA) was prepared by embedding 1,4-bis (benzoxazol-1-ylidene) phthalimide (BBOB) in plasticized polyvinyl chloride Iodazole fiber optic sensor. Quenching mechanisms include the primary filtration effect of metronidazole and the role of metronidazole in forming a charge-transfer complex with BBOB. The sensor has good reversibility, the response time is less than 30s, the linear range of response is 4.00 × 10-6 ~ 1.00 × 10-4mol / L, the detection limit is 1.00 × 10-6mol / L, The relative deviation of 10-4 mol / L metronidazole was 0.82% (n = 10). Common inorganic ions, the drug does not affect the determination of metronidazole, the determination of metronidazole in commercial preparations and pharmacopoeia consistent.