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[目的]分析本院血液透析（血透）患者中心静脉导管相关性血流感染发生率、危险因素、细菌谱及药敏结果，探讨感染的防治措施。[方法]回顾性分析本院2009年8月至2013年7月359例血透置管患者资料，并作统计学分析。[结果]24例患者确诊导管相关性血流感染，感染率为6．68％，留置时间、患糖尿病为感染危险因素，金黄色葡萄球菌、表皮葡萄球菌是导管感染最常见细菌。[结论]中心静脉导管存在较高感染率，缩短留置时间、持续质量改进、加强病原菌监测可降低导管感染的发生。“,”[Objective]To analyze the incidence ,risk factors ,bacterial spectrum and antibiotic susceptibility of central venous catheter related bloodstream infection (CRBI) ,and to explore the treatment and prevention measures of infection .[Methods]The data of 359 hemodialysis patients in our hospital from Aug .2009 to July 2013 were analyzed retrospectively .Statistical analysis was taken .[Results]Among all patients ,24 patients were diagnosed as CRBI .The incidence of CRBI was 2 .25 times per 1 ,000 catheter days .The indwelling time and diabetes mellitus were the risk factors of CRBI .The most common pathogens were Staphylococcus aureus and Staphylococcus epidermidis .[Conclusion]Central venous catheter has high infection rate .Shortening the indwelling time ,improving the quality continuously and strengthening the pathogen monitoring can reduce the incidence of CRBI .