Aim:As conflict caused by cultural diversity among patients in China continues to rise,hospitals are in urgent need for improvement of transcultural efficacy among nurses.This study aims to evaluate the transcultural self-efficacy of nurses working in the tertiary general hospital in Guizhou Province,an ethnic minority region in west China,and to identify whether nurses’ demographic characteristics affect their transcultural self-efficacy.Method:We used the Chinese version of the Transcultural Self-Efficacy Tool (TSET-CV) to survey 1,190 inservice nurses.Results:Results showed that the level of transcultural self-efficacy of the nurses was generally moderate;few of the nurses had high or low transcultural self-efficacy.The nurses’ transcultural self-efficacy was affected by demographic variables,including age,marital status,employment type,income,work experience,and whether or not they were head nurses.Having a stable work environment,a stable marriage,a good educational background,and a high-ranked professional title were associated with increased transcultural self-efficacy.Conclusion:Nursing administrators in hospitals should offer continuing education on transcuitural nursing according to nurses’ demographic characteristics and the SEST scores.