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目的:探讨参附注射液对下肢缺血再灌注诱发心肌损伤的保护作用。方法:40例拟行下肢骨科手术病人被随机分成2组,每组20例。所有病人均选择腰硬联合麻醉,对照组采用常规治疗,参附组在常规治疗的基础上在手术开始前加用参附注射液中静脉输注。分别从肘静脉采松止血带前(T1)、松止血带后30min(T2)、松止血带后120min(T3)等时间点血液,分离血清,检测肌钙蛋白I(cTnI),心肌酶谱。结果:与T1相比较,T2及T3时点的cTnI显著性增高(P<0.01),且在T3时点达到最高值。与对照组相比较,参附组T2及T3时点的cTnI增高的幅度显著降低(P<0.01)。结论:参附注射液能够降低心肌酶升高的幅度,对肢体缺血再灌注心肌损伤具有显著的保护作用。
Objective: To investigate the protective effects of Shenfu injection on myocardial injury induced by ischemia-reperfusion in lower extremities. Methods: Forty patients undergoing lower extremity orthopedic surgery were randomly divided into two groups (20 in each group). All patients were selected combined spinal and epidural anesthesia, the control group with conventional treatment, ginseng group on the basis of conventional treatment, before the start of surgery plus Shenfu injection intravenous infusion. Serum levels of cTnI and cTnI were measured respectively from the anterior vena cava (T1), 30 min after releasing the tourniquet (T2) and 120 min after releasing the tourniquet (T3) . Results: Compared with T1, cTnI at T2 and T3 increased significantly (P <0.01), and reached the highest at T3. Compared with the control group, the increase of cTnI at T2 and T3 was significantly decreased (P <0.01). Conclusion: Shenfu injection can reduce the amplitude of myocardial enzymes and have a significant protective effect on myocardial ischemia-reperfusion injury.