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[目的]研究尿多酸肽单药治疗乳腺癌的疗效及毒副作用。[方法]尿多酸肽注射液单药300ml深静脉置管给药 ,每天1次 ,连续4周为1疗程 ,共2疗程 ,观察疗效和不良反应 ,采用EORTCQLQ_C30(V3.0)中文版评估生活质量。[结果]入组病人17例 ,可评价疗效15例 ,PR2例 ,MR1例 ,SD6例 ,PD6例 ,总缓解率13.33% ,总好转率20.00 % ;QLQ_C30生活质量15项领域中位有效改善率50.00% ;可评价不良反应17例 ,主要为消化道反应 ,大多Ⅰ～Ⅱ度 ,Ⅲ度恶心呕吐仅1例 ,且对骨髓、心、肝、肾等主要脏器无毒性反应。[结论]尿多酸肽对乳腺癌具有一定的抗癌作用 ,可明显提高患者生活质量
[Objective] To study the efficacy and toxic side effects of urinary polyacid peptides in the treatment of breast cancer. [Methods] The urinary polypeptidase injection was administered with a single 300ml deep intravenous catheter once a day for 4 weeks as a course of treatment for a total of 2 courses. The efficacy and adverse reactions were observed. The Chinese version of EORTCQLQ_C30 (V3.0) was used for evaluation. Quality of Life. [Results] Among the 17 patients enrolled, 15 patients could be evaluated for efficacy, 2 were PR, 1 was MR, 6 were SD, 6 were PD. The total remission rate was 13.33%, and the total improvement rate was 20.00%. The QLQ_C30 quality of life was effective in 15 areas. 50.00%; Evaluable adverse reactions in 17 cases, mainly for the digestive tract reaction, most of I ~ II degrees, III degree nausea and vomiting only in 1 case, and no toxic reaction to bone marrow, heart, liver, kidney and other major organs. [Conclusion] Urinary Polypeptide has a certain anticancer effect on breast cancer and can significantly improve the quality of life of patients