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目的：为探索西拉普利治疗高血压病疗效及其对胰岛素抗药性的影响。方法：采用随机对照法对原发性高血压３０例（男性１６例，女性１４例，年龄４８±ｓ１０ａ），用西拉普利２．５～５．０ｍｇ／ｄ，疗程４ｗｋ。对照组为２０例（男性１１例，女性９例；年龄５２±７ａ），用氢氯噻嗪２５～５０ｍｇ／ｄ，疗程４ｗｋ。结果：西拉普利和氢氯噻嗪都有明显降压作用，但只有西拉普利有改善胰岛素抗药性的效应。结论：西拉普利治疗高血压病人有改善胰岛素抗药性的作用，对糖代谢起良好的影响。
Objective: To explore the efficacy of cilazapril in the treatment of hypertension and its effect on insulin resistance. Methods: Thirty patients with essential hypertension (16 men and 14 women, age 48 ± s10a) were randomized and randomized to receive cilazapril 2.5-5.0 mg / d for 4 weeks. Control group, 20 cases (11 males and 9 females; age 52 ± 7a), with hydrochlorothiazide 25 ~ 50mg / d, treatment 4wk. RESULTS: Cilazapril and hydrochlorothiazide had a significant antihypertensive effect, but only cilazapril had the effect of improving insulin resistance. CONCLUSION: Cilazapril treatment of hypertension patients have the effect of improving insulin resistance, which has a good effect on glucose metabolism.