头孢菌素合成常采用混合酸酐法、DCC法、活化酯法等肽类合成方法。羰基二咪唑(简称CDI,I)法也属肽类合成方法。最近有文献报道,将此法用于头孢菌素C_3·位乙酰氧基的改造以及氨苄青霉素α-氨基的修饰。但用于头孢菌素C_7位缩合未见报道。本文采用 Cephalosporin synthesis commonly used mixed anhydride method, DCC method, activated ester method peptide synthesis method. Carbonyl diimidazole (CDI, I) method is also a peptide synthesis method. Recently reported in the literature, this method is used for cephalosporin C_3 acetyloxy modification and ampicillin α-amino modification. However, cephalosporin C7 condensation has not been reported. This article uses