论文部分内容阅读
[目的]探讨右美托咪定对肺部手术患者抗氧化能力、一氧化氮(NO)水平及心肺功能的影响.[方法]择期全麻肺部手术患者76例随机分为对照组(C组)和右美托咪定组(D组),各38例.开胸前(T0)、单肺通气(OLV)后60 min(T1)、术毕即刻(T2)检测肿瘤坏死因子(TNF-α)、白介素6(IL-6)、NO、丙二醛(MAD)、超氧化物歧化酶(SOD),并于T0~T2时测定心搏指数(SI)、心脏指数(CI)、气道平台压、气道阻力和肺顺应性;记录两组围手术期不良反应.[结果]与T0时相比,两组T1、T2时TNF-α、IL-10、TNF-α、IL-10、NO、MDA均升高,SOD降低(P0.05),T2时SI、CI均降低,气道平台压、气道阻力、肺顺应性均升高(P0.05) , but SI, CI at T2 were significantly decreased. Airway plateau pressure, airway resistance and lung compliance were significantly in-creased ( P<0.05) . Compared to group C at T2 , SI and CI in group D were significantly higher and airway plateau pres-sure, air way resistance and lung compliance were significantly lower ( P<0.05). The adverse reaction rate during the perioperative period of group D was 7.89%, was significantly lower than that of group C, which was 26.32% ( P<0.05) .[Conclusion] The application of dexmedetomidine in lung surgery during the perioperative period can reduce inflammatory levels and alleviate oxidative stress injury. It is beneficial to the recovery of cardiopulmonary function.