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肿瘤基因组稳定性新机制浙江大学医学院应颂敏教授和沈华浩教授等首次发现肺癌细胞在有丝分裂期(M期)存在D N A复制行为,并发现肿瘤细胞这种在M期的D N A复制是其赖以生存的一个重要机制,相关结果发表在《自然》杂志上。肺癌细胞在有丝分裂期(M期)复制的DNA主要位于“脆性位点”(基因组特定区域),在有丝分裂前期,肺癌细胞会启动核酸酶MUS81、DNA聚合酶
New Mechanism of Tumor Genome Stability Professor Ying-Min Ying and Shen Hua-Hao of Zhejiang University School of Medicine found for the first time that there is DNA replication in lung cancer cells during mitosis (M stage) and found that the DNA replication of tumor cells in M phase is dependent on An important mechanism for survival, the results published in the “Nature” magazine. Lung cancer cells in the mitosis (M phase replication DNA is mainly located in the “brittle site ” (genome-specific regions), in mitosis, lung cancer cells will start nuclease MUS81, DNA polymerase