乳腺Paget病(Paget’s disease of the breast),主要表现为乳头-乳晕区的癌呈湿疹样改变,故又称湿疹样癌,由Paget于1874年首先报告,约占原发性乳腺癌的1%~3%。本病常伴发浸润性乳腺癌或导管原位癌,临床上容易误诊。本病在来源与治疗方面一直存在争议。本文就Paget病的临床病理特征、诊断、治疗及预后作一综述。 Paget’s disease of the breast, which is mainly characterized by eczema-like changes in the papillary-areolar region, is also known as eczema-like carcinoma, first reported by Paget in 1874, accounting for about 1% of primary breast cancer ~ 3%. The disease often accompanied by invasive breast cancer or ductal carcinoma in situ, clinically easy to misdiagnosis. The disease has been controversial in the sources and treatment. This article reviews the clinicopathological features, diagnosis, treatment and prognosis of Paget’s disease.