论文部分内容阅读
目的探讨高同型半胱氨酸(homocysteine,Hcy)与脑卒中之间的关系。方法选取脑卒中病人158例,作为研究组,其中脑梗死101例,脑出血57例。对照组为60例正常人。通过荧光生化法定量检测血中总同型半胱氨酸(Th-cy)的浓度。结果脑梗死组Hcy总平均值(20.45±12.6)mol/L,男性占42.5%,女性占38.1%。进展性Hcy水平升高58.3%。脑出血组Hcy总平均值(19.15±9.77)mol/L,男性占41.8%,女性占39.3%明显升高。正常组男性正常值略高于女性。脑卒中患者与正常对照组,(P<0.01),且脑梗死组与及出血组之间差异无显著性,(P<0.05)。结论高同型半胱氨酸水平明显高于正常的独立危险因素,高Hcy患者易发生脑卒中,脑卒中并高Hcy者,病程迁延,复发率高。
Objective To investigate the relationship between homocysteine (Hcy) and stroke. Methods 158 stroke patients were selected as the research group, including 101 cases of cerebral infarction and 57 cases of cerebral hemorrhage. Control group of 60 normal subjects. The concentration of total homocysteine (Th-cy) in the blood was quantitatively determined by fluorescence biochemistry. Results The average Hcy in cerebral infarction group was (20.45 ± 12.6) mol / L, with 42.5% in male and 38.1% in female. Progressive Hcy levels increased by 58.3%. The average value of Hcy in cerebral hemorrhage group was (19.15 ± 9.77) mol / L, 41.8% in male and 39.3% in female. The normal group of normal male slightly higher than women. Stroke patients and normal control group, (P <0.01), and there was no significant difference between cerebral infarction group and hemorrhage group (P <0.05). Conclusions High homocysteine levels were significantly higher than those of normal independent risk factors. Patients with high Hcy were prone to stroke, stroke and high Hcy, with prolonged course and high recurrence rate.