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目的 通过检测小儿哮喘患者血中ET -1、NO含量变化 ,及胸部X线变化 ,探讨ET -1、NO对小儿哮喘气道重塑的作用。方法 在哮喘急性期、缓解期 1月 ,分别检测 63例患儿血ET -1、NO水平 ,1a后检测 2 0例 ,并分别拍摄胸部正位片 63例。结果 急性期ET -1、NO明显高于正常对照组 ,缓解期 1月 ,1a时ET -1仍明显增高。肺间质样改变在缓解期 1月时比率增高 ,1a有所降低 ,但仍占 2 8.6%。结论 ET -1、NO参与了小儿哮喘的急性发病及缓解期的气道修复 ,对气道重塑具有重要影响 ,小儿气道损伤的修复具有可逆性。
Objective To investigate the effects of ET-1 and NO on airway remodeling in children with asthma by detecting the changes of ET-1 and NO in blood and the changes of chest X-ray. Methods In the acute phase of asthma and remission in January, the levels of ET-1 and NO in 63 children were detected respectively. 20 cases were detected after 1a, and 63 cases of anteroposterior radiographs were taken respectively. Results The levels of ET-1 and NO in acute phase were significantly higher than those in normal control group. The interstitial lung changes in the remission period in January increased, 1a decreased, but still accounted for 8.66%. Conclusions ET-1 and NO are involved in the acute onset of pediatric asthma and airway repair during remission, which have an important effect on airway remodeling. The repair of airway injury in children is reversible.