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本文对２８例优降糖继发失效及２３例有效的非胰岛素依赖型糖尿病病人分别进行优降糖敏感性试验、胰岛素耐量试验、胰高糖素Ｃ肽刺激试验及标准馒头餐试验，比较两组病人试验结果的差异，分析失效组病人个体各项试验结果的特点，说明结合四项基本临床试验可从磺脲类药物抵抗性、胰岛素敏感性、Ｂ细胞贮备功能及葡萄糖介导的胰岛素分泌反应等不同环节，探讨磺脲类药物继发失效的原因及发生机理，分析个体病人的临床特征，指导治疗。
This article 28 cases of secondary hypoglycemic failure and 23 cases of non-insulin-dependent diabetes mellitus patients with glycometabolic glucose tolerance test, insulin resistance test, glucagon peptide stimulation test and standard steamed bread meal test, compare two The differences of the test results of the patients and the characteristics of the individual test results of the patients in the failure group indicate that combining the four basic clinical trials shows that the combination of sulfonylurea resistance, insulin sensitivity, B cell reserve function and glucose-mediated insulin secretion Reaction and other different links to explore the secondary failure of sulfonylureas causes and mechanism of occurrence, analysis of the clinical characteristics of individual patients, and guide the treatment.