目前,角膜缘移植术已成为重建角膜上皮的重要手段,但尚少对角膜缘干细胞生存微环境的深入研究。本文通过温习近10年来有关角膜缘干细胞研究的文献,着重论述在角膜缘干细胞生存微环境中对干细胞的增生和分化有重要影响的因素以及影响干细胞凋亡的主要因素。旨在提供通过改善干细胞生存微环境,提高角膜表面重建术的成功率。 At present, limbal transplantation has become an important means of reconstructing corneal epithelium, but few studies on the survival microenvironment of limbal stem cells. By reviewing the literature on limbal stem cells in the past 10 years, this review focuses on the important factors that affect stem cell proliferation and differentiation in the limbic stem cell microenvironment, as well as the main factors affecting the apoptosis of stem cells. The aim is to improve the success rate of corneal surface reconstruction by improving the microenvironment of stem cell survival.