近几年发现某些化疗药物在低剂量、长时间接触中可选择性抑制血管内皮细胞的功能 ,且不受肿瘤细胞耐药状态的影响 ,从而为以肿瘤血管内皮细胞为靶位的化疗展示了良好的前景。现系统阐述抗血管生成化疗的理论依据、药物筛选标准、研究方法和化疗药物研究现状 In recent years, some chemotherapeutic drugs have been found to selectively inhibit the function of vascular endothelial cells in low-dose, long-term exposure, and are not affected by the drug resistance of tumor cells, thus providing a chemotherapeutic target targeting tumor vascular endothelial cells A good prospect. Now systematically explain the theoretical basis of anti-angiogenic chemotherapy, drug screening criteria, research methods and status of chemotherapy drugs