为探讨α-干扰素（IFN-α）治疗能否阻止慢性活动性丙型肝炎伴肝硬变病人发展为肝细胞癌，作者作了前瞻性随机对照试验。人选病人均有1年以上血谷雨转氨酶（ALT）异常，HBsAg阴性，除外HCV以外的肝病，Child－Pugh评分为A级代偿性肝硬化，而且超声、CT、闪烁成像均未见可疑肝癌 To investigate whether interferon-α (IFN-α) therapy can prevent the development of hepatocellular carcinoma in patients with chronic active hepatitis C and cirrhosis, a prospective randomized controlled trial was conducted. All patients had ALT abnormalities more than 1 year, HBsAg negative, except liver disease other than HCV, Child-Pugh score grade A compensated cirrhosis, and no suspicious liver cancer by ultrasound, CT, scintigraphy