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外周性性早熟主要由于性腺、肾上腺等分泌性激素异常或外源性性激素所引起,是不受控于下丘脑-垂体-性腺轴的青春发动。其病因复杂多样,可为先天遗传性或获得性疾病所引起。引起外周性性早熟的重要病因有McCune-Albright综合征、孤立性卵巢囊肿、家族性男性性早熟、先天性肾上腺皮质增生症、肾上腺肿瘤、分泌绒毛膜促性腺激素的肿瘤、卵巢肿瘤等。近年来分子生物学的进展使得其中部分病因的发病机制得以阐明。
Peripheral precocious puberty mainly due to abnormal secretion of sex hormones such as the gonads, adrenal glands or exogenous sex hormones, is not controlled by the hypothalamus - pituitary - gonadal axis of youthful start. Its complex and diverse causes may be caused by congenital or acquired diseases. Important causes of peripheral precocious puberty are McCune-Albright syndrome, isolated ovarian cysts, familial precocious puberty, congenital adrenal hyperplasia, adrenal tumors, hCG-secreting tumors, and ovarian tumors. The progress of molecular biology in recent years has made it possible to elucidate the pathogenesis of some of these causes.