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目的利用二维化学位移成像(2DCSI)检测帕金森病(PD)的基底神经节代谢物浓度。探讨PD的基底神经节代谢物浓度是否变化。评估2DCSI技术检测PD的价值。资料与方法符合临床诊断标准的PD患者26例。从健康志愿者中抽取与PD组年龄、性别相匹配的26名健康者作为正常对照组。采用2DCSI技术检测所有入组对象的双侧豆状核、尾状核的代谢物浓度,包括氮-乙酰天门冬氨酸/肌酸复合物(NAA/Cr),氮-乙酰天门冬氨酸/胆碱复合物(NAA/Cho)以及Cho/Cr比值。比较PD组和正常对照组的基底神经节相对应核团的代谢物浓度之间的差异。结果PD组双侧豆状核的NAA/Cho和右尾状核的NAA/Cr、左侧尾状核的Cho/Cr比值明显低于正常对照组(P<0.05)。左侧豆状核Cho/Cr比值明显高于正常对照组(P<0.05)。结论PD患者的基底神经节代谢物浓度与正常人有差异。2DCSI作为一种可用于检测基底神经节代谢物浓度的无创伤性的方法,将成为检测正常脑的生理性和病变脑的病理性代谢物浓度的变化,尤其是神经元变性性疾病的一种重要手段。
Objective To detect basal ganglia metabolite concentrations in Parkinson’s disease (PD) using two-dimensional chemical shift imaging (2DCSI). To investigate whether PD concentrations of basal ganglia metabolites change. Assess the value of 2DCSI to detect PD. Materials and Methods 26 cases of PD patients meeting the clinical diagnostic criteria. Twenty-six healthy subjects matched with the age and sex of PD group were selected as normal control group from healthy volunteers. The concentrations of metabolites in both lentiform nucleus and caudate nucleus of all enrolled subjects, including NAA / Cr, N-acetyl-aspartic acid / Choline Complex (NAA / Cho) and Cho / Cr ratio. Differences in metabolite concentrations in the basal ganglia corresponding nuclei between the PD group and the normal control group were compared. Results NAA / Cho in bilateral lentiform nucleus and NAA / Cr in right caudate nucleus and Cho / Cr ratio in left caudate nucleus in PD group were significantly lower than those in normal control group (P <0.05). The Cho / Cr ratio of left lentiform nucleus was significantly higher than that of normal control group (P <0.05). Conclusions The concentration of basal ganglia metabolites in PD patients is different from that in normal subjects. As a noninvasive method that can be used to detect the concentration of metabolites in basal ganglia, 2DCSI will be a test for the detection of changes in the physiological and diseased brain pathological metabolites in normal brain, especially in neuronal degenerative diseases Important means.