论文部分内容阅读
目的利用磁共振弥散张量成像(DTI)技术,观察养血清脑颗粒治疗卒中后抑郁(PSD)的疗效差异,以及其对脑白质结构改变的影响。方法给予卒中后抑郁患者养血清脑颗粒4 g,口服,3次/d;疗程12 w,治疗前、后均收集汉密尔顿抑郁量表评分(HAMD-24)、DTI扫描数据。治疗后HAMD-24≤8分纳入治愈组,反之纳入难治组。比较两组治疗前、后FA值变化情况。结果养血清脑颗粒治愈率约44.6%。与治疗前相比,治愈组的左侧额叶FA值治疗后明显升高(P<0.05);比较两组治疗前的FA值,发现难治组左侧额叶、右侧海马的基线FA值低下(P<0.05)。结论养血清脑颗粒治疗PSD有效。PSD患者存在可逆性前额叶深部白质损伤;且难治性PSD患者左侧额叶、右侧海马的基线FA值低下,提示DTI可作为抗抑郁疗效评估的预测指标。
Objective To observe the therapeutic effect of Yangxue Qingnao Granules on post-stroke depression (PSD) by using magnetic resonance diffusion tensor imaging (DTI) and its effect on the structural changes of white matter. Methods Patients with post-stroke depression were treated with nourishing qingnao granule 4 g orally for 3 times daily for 12 weeks. The Hamilton Depression Rating Scale (HAMD-24) and DTI scan data were collected before and after treatment. After treatment, HAMD-24≤8 points were included in the cured group, otherwise, they were included in the refractory group. The changes of FA values before and after treatment were compared between the two groups. Results Yangxue Qingnao particles cure rate of about 44.6%. Compared with those before treatment, FA values in the left frontal lobe of the treated group were significantly increased after treatment (P <0.05). The FA values of the two groups were compared before treatment and the baseline FA of the left frontal lobe and right hippocampus were found in the refractory group Value was low (P <0.05). Conclusion Yangxue Qingnao Granules in treating PSD is effective. PSD patients with reversible prefrontal lobe deep white matter damage; and refractory PSD patients with left frontal lobe and right hippocampus baseline FA value low, suggesting that DTI can be used as a predictor of antidepressant efficacy evaluation.