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目的:初步探讨非罗伯逊型复发性t(11;22)(q23;q11)染色体平衡易位的发生机制。方法:外周血染色体核型分析检测有不孕不育或不良生育史的4例患者的染色体核型。结果:4例t(11;22)(q23;q11)易位患者,染色体断裂位点一致,患者间无亲缘关系,均有不良生育史,其中2例女性表现为反复流产,2例男性患者表现为精子数目减少和活力下降的。结论:t(11;22)(q23;q11)是一种较为少见的非罗伯逊易位型复发性平衡易位,对t(11;22)(q23;q11)深入研究有助于进一步完善染色体畸变的理论基础。
Objective: To investigate the mechanism of non-Robertson recurrence t (11; 22) (q23; q11) chromosomal equilibrium translocation. Methods: Chromosome karyotype analysis of peripheral blood was used to detect the karyotype of 4 patients with infertility or poor fertility history. Results: Four patients with t (11; 22) (q23; q11) translocations had the same chromosomal cleavage site and no unrelated patients. All of them had an unfavorable history of childbirth. Two of the women showed recurrent abortion and two male patients The performance of the number of sperm decreased and decreased vitality. Conclusion: t (11; 22) (q23; q11) is a relatively rare non-Robertsonian translocation equilibrium translocation, further study of t (11; 22) (q23; q11) The theoretical basis of distortion.