多能干细胞在人类疾病的细胞代替性治疗中有巨大的应用前景,但干细胞在扩增培养过程中常发生遗传物质变异,阻碍了干细胞的安全应用。相对于分化细胞,多能干细胞有其独特的方式维持遗传物质的稳定。但这些独特方式的分子基础尚不明了,也未厘清有哪些干细胞特异因子参与其中。研究干细胞维持遗传物质稳定性的独特调控机理可使我们能更全面地了解干细胞的特性,并有助于解决培养过程产生的安全隐患。 Pluripotent stem cells have great potential applications in cell replacement therapy for human diseases. However, stem cell proliferation often occurs during the expansion of genetic material variation, hindering the safe application of stem cells. Relative to differentiated cells, pluripotent stem cells have their own unique way of maintaining genetic material stability. However, the molecular basis of these unique modalities is not yet known, nor does it clarify which stem cell specific factors are involved. The unique mechanism by which stem cells maintain the stability of genetic material allows us to understand more fully the characteristics of stem cells and help to address the potential safety hazards associated with the cultivation process.