目的：探讨创伤反应性中枢神经系统（ＣＮＳ）间接受损的可能机制。方法：借助犬双后肢低、高速投射物致伤模型，观察了边缘系下丘脑、海马及颞顶区脑组织髓鞘碱性蛋白（ＭＢＰ）表达及超微结构改变。结果：伤后８ｈ低速组下丘脑ＭＢＰ－ｍＲＮＡ表达增强（Ｐ＜００１）；高速组下丘脑、海马ＭＢＰ含量明显增高（Ｐ＜００１），ＭＢＰ－ｍＲＮＡ表达增强（Ｐ＜００１）；超微结构改变以高速组下丘脑、海马为著，多集中于神经元、神经纤维及毛细血管内皮细胞变化。结论：边缘系下丘脑、海马选择性易损，可能为创伤反应性ＣＮＳ异常的重要病理生理基础 Objective: To explore the possible mechanism of indirect damage of traumatic reactive central nervous system (CNS). Methods: By means of low and high speed projectile injuring models with double hind limbs, we observed the expression of MBP and the ultrastructure changes in the hypothalamus, hippocampus and temporomandibular area of ​​the marginal line. Results: The expression of MBP-mRNA in the hypothalamus of low-speed group increased significantly (P <001) 8 h after injury; the content of MBP in hypothalamus and hippocampus of high-speed group increased significantly (P <001) and MBP-mRNA expression increased 01); ultrastructural changes in the high-speed group of the hypothalamus, hippocampus as much focus on neurons, nerve fibers and capillary endothelial cell changes. CONCLUSION: Selective marginal hippocampal and hippocampal selective vulnerability may be an important pathophysiological basis for traumatic CNS abnormalities