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本文应用成年去胸腺或去性腺Wistar大鼠研究了胸腺对肝脏脂质过氧化(LPO)的影响及其与性激素有关的中间途径,结果表明,雌性成年去胸腺(ATx)大鼠肝匀浆丙二醛(MDA)含量增高,但雄性ATx大鼠肝脏MDA无明显变化;同时雌性ATx大鼠血浆雌二醇水平下降,雄性ATx大鼠血浆睾酮浓度降低,雌性大鼠卵巢切除术后肝脏MDA的变化与胸腺切除术后的变化相似,给予雌二醇可逆转去卵巢大鼠肝脏MDA的增高,在雄性大鼠中,无论是切除睾丸还是睾丸切除后补充睾酮对肝脏MDA均无明显影响,此外,给雌性ATx大鼠注射雌二醇可逆转其肝脏MDA的增高,这些结果提示胸腺在调节雌性大鼠肝脏抗氧化功能中起着重要作用,这种作用可能通过雌激素介导,因此我们设想在体内可能存在:胸腺-雌激素-肝脏通路”,它参与对肝脏抗氧化功能的调节。
The effect of thymus on hepatic lipid peroxidation (LPO) and its intermediate pathways related to sex hormones were studied in adult thymic or gonadal Wistar rats. The results showed that female adult dethymic (ATx) rat liver homogenate C Dialdehyde (MDA) content increased, but there was no significant change in liver MDA in male ATx rats; plasma estradiol levels decreased in female ATx rats, plasma testosterone concentrations decreased in male ATx rats, and liver MDA in female rats after ovariectomy. The change was similar to the change after thymectomy. Estradiol could reverse the increase of MDA in the liver of ovariectomized rats. In male rats, neither testosterone nor testosterone supplementation had significant effect on liver MDA. The injection of estradiol into female ATx rats reversed the increase of MDA in the liver. These results suggest that the thymus plays an important role in regulating the antioxidant function of the female rat liver. This effect may be mediated by estrogen, so we envisage that It may exist in the body: the thymus-estrogen-liver pathway, which is involved in the regulation of liver antioxidant function.