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目的 :观察肺癌患者血浆及纤支镜灌洗液中ET、CGRP浓度 ,探讨ET、CGRP在肺癌诊断中的应用。方法 :用RIA测定健康人对照组和肺癌患者血浆中ET、CGRP浓度 ;0 9%NS灌洗液和肺癌患者纤支镜提取灌洗液中ET、CGRP浓度。结果 :患者血浆及灌洗液ET、CGRP含量显著高于健康对照组 (P <0 0 0 1) ;肺癌患者灌洗液与0 9%NS纤支镜灌洗液对照组差异有显著性 (P <0 0 0 1)。结论 :观察肺癌患者ET、CGRP血浆及灌洗液中的浓度 ,对研究肺癌发生发展及诊断具有重大意义
Objective: To observe the concentrations of ET and CGRP in plasma and bronchoalveolar lavage fluid in patients with lung cancer, and to explore the application of ET and CGRP in the diagnosis of lung cancer. Methods : Plasma ET and CGRP concentrations in control subjects and lung cancer patients were measured by RIA; 9% NS lavage fluid and lung cancer patients were extracted by bronchoscopy to determine ET and CGRP concentrations. Results: Plasma and lavage fluid levels of ET and CGRP in patients were significantly higher than those in healthy controls (P < 0 01). There was a significant difference between lavage fluid and 0 9% NS bronchoalveolar lavage fluid in the control group. P < 0 0 0 1). Conclusion : Observing the concentrations of ET and CGRP in plasma and lavage fluid in patients with lung cancer is of great significance for the study of the occurrence, development and diagnosis of lung cancer.